https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44961 2+ signalling in key events of cancer cell function and tumour progression, such as proliferation, migration, invasion and survival, has recently begun to be appreciated. Many cellular Ca²⁺-stimulated signalling cascades utilise the intermediate, calmodulin (CaM). The Ca²⁺/CaM complex binds and activates a variety of enzymes, including members of the multifunctional Ca²⁺/calmodulin-stimulated protein kinase (CaMK) family. These enzymes control a broad range of cancer-related functions in a multitude of tumour types. Herein, we explore the cancer-related functions of these kinases and discuss their potential as targets for therapeutic intervention.]]> Tue 25 Oct 2022 13:45:27 AEDT ]]> Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51198 Thu 24 Aug 2023 15:01:24 AEST ]]> Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43246 Thu 15 Sep 2022 10:17:31 AEST ]]> Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33473 Thu 09 Dec 2021 11:01:36 AEDT ]]> miR-518f-5p decreases tetraspanin CD9 protein levels and differentially affects non-tumourigenic prostate and prostate cancer cell migration and adhesion https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33474 Thu 03 Feb 2022 12:18:02 AEDT ]]> Tetraspanin CD9 is regulated by MiR-518f-5p and functions in breast cell migration and in vivo tumor growth https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44184 Mon 10 Oct 2022 10:48:32 AEDT ]]> A novel role for brain and acute leukemia cytoplasmic (BAALC) in human breast cancer metastasis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39586 in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion were determined in vitro. We demonstrate herein that BAALC expression is progressively increased in primary and breast cancer metastases when compared to normal breast tissue. Increased BAALC mRNA is associated with a reduction in DMFS and disease-free survival, but not OS, in breast cancer patients, even when corrected for tumor grade. We show that overexpression of BAALC in MCF-7 breast cancer cells increases the proliferation, anchorage-independent growth, invasion, and migration capacity of these cells. Conversely, siRNA knockdown of BAALC expression in Hs578T breast cancer cells decreases proliferation, invasion and migration. We identify that this BAALC associated migration and invasion is mediated by focal adhesion kinase (FAK)-dependent signaling and is accompanied by an increase in matrix metalloproteinase (MMP)-9 but not MMP-2 activity in vitro. Our data demonstrate a novel function for BAALC in the control of breast cancer metastasis, offering a potential target for the generation of anti-cancer drugs to prevent breast cancer metastasis.]]> Mon 08 Aug 2022 11:48:18 AEST ]]> Proteomic and phosphoproteomic characterisation of primary mouse embryonic fibroblasts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55064 Mon 08 Apr 2024 12:38:40 AEST ]]> Glioblastoma multiforme: an overview of emerging therapeutic targets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39977 Fri 22 Jul 2022 11:56:18 AEST ]]>